Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Pu, Wei-ling; Sun, Li-kang; Gao, Xiu-mei; Rüegg, Curzio; Cuendet, Muriel; Hottiger, Micheal O.; Zhou, Kun; Miao, Lin; Zhang, Yun-sha; Gebauer, Margaret

doi:10.1007/s11655-017-2974-y

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Journal article

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Pu, Wei-ling Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, University of Traditional Chinese Medicine, Tianjin, China
Sun, Li-kang Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, University of Traditional Chinese Medicine, Tianjin, China - Tianjin State Key Laboratory of Modern Chinese Medicine, University of Traditional Chinese Medicine, Tianjin, China - School of Integrative MedicineTianjin University of Traditional Chinese Medicine, Tianjin, China
Gao, Xiu-mei Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, University of Traditional Chinese Medicine, Tianjin, China - Tianjin State Key Laboratory of Modern Chinese Medicine, University of Traditional Chinese Medicine, Tianjin, China
Rüegg, Curzio Pathology Unit, Department of Medicine, University of Fribourg, Switzerland
Cuendet, Muriel School of Pharmaceutical Sciences, University of Geneva, Switzerland
Hottiger, Micheal O. Department of Molecular Mechanisms of DiseaseUniversity of Zurich-Irchel, Zurich, Switzerland
Zhou, Kun Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, University of Traditional Chinese Medicine, Tianjin, China - Tianjin State Key Laboratory of Modern Chinese Medicine, University of Traditional Chinese Medicine, Tianjin, China
Miao, Lin Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, University of Traditional Chinese Medicine, Tianjin, China - Tianjin State Key Laboratory of Modern Chinese Medicine, University of Traditional Chinese Medicine, Tianjin, China - Department of Molecular Mechanisms of DiseaseUniversity of Zurich-Irchel, Zurich, Switzerland
Zhang, Yun-sha School of Integrative MedicineTianjin University of Traditional Chinese Medicine, Tianjin, China - Pathology Unit, Department of Medicine, University of Fribourg, Switzerland
Gebauer, Margaret ChingcuraCenter for Traditional Chinese Medicine, Zurich, Switzerland

01.10.2017

Published in:

Chinese Journal of Integrative Medicine. - 2017, vol. 23, no. 10, p. 723–732

English Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica (CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine (CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment (TME). Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis and immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language