Journal article

Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys

  • Badoud, Simon Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Borgognon, Simon Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Cottet, Jérôme Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Chatagny, Pauline Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Moret, Véronique Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Fregosi, Michela Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Kaeser, Mélanie Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Fortis, Ekaterina Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Schmidlin, Eric Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
  • Bloch, Jocelyne Department of NeurosurgeryLausanne University Hospital (CHUV)LausanneSwitzerland
  • Brunet, Jean-François Department of NeurosurgeryLausanne University Hospital (CHUV)LausanneSwitzerland
  • Rouiller, Eric M. Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition CenterUniversity of Fribourg, Switzerland
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    01.04.2017
Published in:
  • Brain Structure and Function. - 2017, vol. 222, no. 3, p. 1193–1206
English In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the “modified-Brinkman board” task and the “reach and grasp drawer” task. The aim of the present study was to extend preliminary data on the role of the prefrontal cortex in motor habit and test the hypothesis that dlPFC contributes to predict the grip force required when a precise level of force to be generated is known beforehand. As expected for a small dlPFC biopsy, neither the motor performance (score) nor the spatiotemporal motor sequences were affected in the “modified- Brinkman board” task, whereas significant changes (mainly decreases) in the maximal grip force (force applied on the drawer knob) were observed in the “reach and grasp drawer” task. The present data in the macaque monkey related to the prediction of grip force are well in line with the previous fMRI data reported for human subjects. Moreover, the ANCE transplantation strategy (in the case of stroke or Parkinson’s disease) based on biopsy in dlPFC does not generate unwanted motor consequences, at least as far as motor habit and motor performance are concerned in the context of a sequential grasping a small objects, which does not require the development of significant force levels.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/305711
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