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Journal article

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

  • Jain, Manish Cardiology, Department of Medicine, University of Fribourg and Hospital of Fribourg, Switzerland
  • Zellweger, Matthieu Medical Photonics Group, LCOM-ISIC, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland
  • Wagnières, Georges Medical Photonics Group, LCOM-ISIC, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland
  • Bergh, Hubert van den Medical Photonics Group, LCOM-ISIC, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland
  • Cook, Stéphane Cardiology, Department of Medicine, University of Fribourg and Hospital of Fribourg, Switzerland
  • Giraud, Marie-Noëlle Cardiology, Department of Medicine, University of Fribourg and Hospital of Fribourg, Switzerland
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    01.04.2017
Published in:
  • Cardiovascular Therapeutics. - 2017, vol. 35, no. 2, p. e12238
Atherosclerosis
Laser
Photodynamic therapy
Photosensitizers
Restenosis
Theranostic
English Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a “vulnerable” state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)-induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/305624
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