Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells
- Priebe, Magdalena Department of Chemistry, University of Fribourg, Switzerland
- Widmer, Jérôme Department of Medicine, University of Fribourg, Switzerland
- Löwa, Nina Suhartha Department of Medicine, University of Fribourg, Switzerland
- Abram, Sarah-Luise Department of Chemistry, University of Fribourg, Switzerland
- Mottas, Inès Department of Medicine, University of Fribourg, Switzerland
- Woischnig, Anne-Kathrin Department of Biomedicine, University Hospital Basel, Basel, Switzerland
- Brunetto, Priscilla S. Department of Chemistry, University of Fribourg, Switzerland
- Khanna, Nina Department of Biomedicine, University Hospital Basel, Basel, Switzerland
- Bourquin, Carole Department of Medicine, University of Fribourg, Switzerland
- Fromm, Katharina M. Department of Chemistry, University of Fribourg, Switzerland
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19.08.2016
Published in:
- Nanomedicine: Nanotechnology, Biology and Medicine. - 2017, vol. 13, no. 1, p. 11–22
English
The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO2) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 288596
- DOI 10.1016/j.nano.2016.08.002
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305508
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