Vesicle origami: cuboid phospholipid vesicles formed by template‐free self‐assembly

Neuhaus, Frederik; Mueller, Dennis; Tanasescu, Radu; Balog, Sandor; Ishikawa, Takashi; Brezesinski, Gerald; Zumbuehl, Andreas

doi:10.1002/anie.201701634

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Vesicle origami: cuboid phospholipid vesicles formed by template‐free self‐assembly

Neuhaus, Frederik Department of Chemistry, University of Fribourg, Fribourg, Switzerland - National Centres of Competence in Research in Chemical Biology (Geneva) and Bio-inspired Materials, Fribourg, Switzerland
Mueller, Dennis Department of Chemistry, University of Fribourg, Fribourg, Switzerland
Tanasescu, Radu Department of Chemistry, University of Fribourg, Fribourg, Switzerland
Balog, Sandor Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
Ishikawa, Takashi Paul Scherrer Institute (PSI), Villigen PSI, Switzerland
Brezesinski, Gerald Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
Zumbuehl, Andreas Department of Chemistry, University of Fribourg, Fribourg, Switzerland - National Centres of Competence in Research in Chemical Biology (Geneva) and Bio-inspired Materials, Fribourg, Switzerland

01.06.2017

Published in:

Angewandte Chemie International Edition. - 2017, vol. 56, no. 23, p. 6515–6518

English Phospholipid liposomes are archetypical self-assembled structures. To minimize the surface tension, the vesicles typically are spherical. Deciphering the bilayer code, the basic physical interactions between phospholipids would allow these molecules to be utilized as building blocks for novel, non-spherical structures. A 1,2- diamidophospholipid is presented that self-assembles into a cuboid structure. Owing to intermolecular hydrogen bonding, the bilayer membranes form an exceptionally tight subgel packing, leading to a maximization of flat structural elements and a minimization of any edges. These conditions are optimized in the geometrical structure of a cube. Surprisingly, the lateral surface pressure in the membrane is only one third of the value typically assumed for a bilayer membrane, questioning a long-standing rule-of-thumb.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language