Vesicle origami: cuboid phospholipid vesicles formed by template‐free self‐assembly
- Neuhaus, Frederik Department of Chemistry, University of Fribourg, Fribourg, Switzerland - National Centres of Competence in Research in Chemical Biology (Geneva) and Bio-inspired Materials, Fribourg, Switzerland
- Mueller, Dennis Department of Chemistry, University of Fribourg, Fribourg, Switzerland
- Tanasescu, Radu Department of Chemistry, University of Fribourg, Fribourg, Switzerland
- Balog, Sandor Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
- Ishikawa, Takashi Paul Scherrer Institute (PSI), Villigen PSI, Switzerland
- Brezesinski, Gerald Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
- Zumbuehl, Andreas Department of Chemistry, University of Fribourg, Fribourg, Switzerland - National Centres of Competence in Research in Chemical Biology (Geneva) and Bio-inspired Materials, Fribourg, Switzerland
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01.06.2017
Published in:
- Angewandte Chemie International Edition. - 2017, vol. 56, no. 23, p. 6515–6518
English
Phospholipid liposomes are archetypical self-assembled structures. To minimize the surface tension, the vesicles typically are spherical. Deciphering the bilayer code, the basic physical interactions between phospholipids would allow these molecules to be utilized as building blocks for novel, non-spherical structures. A 1,2- diamidophospholipid is presented that self-assembles into a cuboid structure. Owing to intermolecular hydrogen bonding, the bilayer membranes form an exceptionally tight subgel packing, leading to a maximization of flat structural elements and a minimization of any edges. These conditions are optimized in the geometrical structure of a cube. Surprisingly, the lateral surface pressure in the membrane is only one third of the value typically assumed for a bilayer membrane, questioning a long-standing rule-of-thumb.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 288917
- DOI 10.1002/anie.201701634
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305506
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