Interaction of biomedical nanoparticles with the pulmonary immune system

Blank, Fabian; Fytianos, Kleanthis; Seydoux, Emilie; Rodriguez-Lorenzo, Laura; Petri-Fink, Alke; Garnier, Christophe von; Rothen-Rutishauser, Barbara

doi:10.1186/s12951-016-0242-5

Back

Journal article

Interaction of biomedical nanoparticles with the pulmonary immune system

Blank, Fabian Respiratory Medicine, Bern University Hospital, University of Bern, Switzerland
Fytianos, Kleanthis Adolphe Merkle Institute, University of Fribourg, Switzerland
Seydoux, Emilie Respiratory Medicine, Bern University Hospital, University of Bern, Switzerland
Rodriguez-Lorenzo, Laura Adolphe Merkle Institute, University of Fribourg, Switzerland
Petri-Fink, Alke Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland
Garnier, Christophe von Respiratory Medicine, Bern University Hospital, University of Bern, Switzerland
Rothen-Rutishauser, Barbara Adolphe Merkle Institute, University of Fribourg, Switzerland

2017

Published in:

Journal of Nanobiotechnology. - 2017, vol. 15, p. 6

English Engineered nanoparticles (NPs) offer site-specific delivery, deposition and cellular uptake due to their unique physicochemical properties and were shown to modulate immune responses. The respiratory tract with its vast surface area is an attractive target organ for innovative immunomodulatory therapeutic applications by pulmonary administration of such NPs, enabling interactions with resident antigen-presenting cells (APCs), such as dendritic cells and macrophages. Depending on the respiratory tract compartment, e.g. conducting airways, lung parenchyma, or lung draining lymph nodes, APCs extensively vary in their number, morphology, phenotype, and function. Unique characteristics and plasticity render APC populations ideal targets for inhaled specific immunomodulators. Modulation of immune responses may operate in different steps of the immune cell-antigen interaction, i.e. antigen uptake, trafficking, processing, and presentation to T cells. Meticulous analysis of the immunomodulatory potential, as well as pharmacologic and biocompatibility testing of inhalable NPs is required to develop novel strategies for the treatment of respiratory disorders such as allergic asthma. The safe-by-design and characterization of such NPs requires well coordinated interdisciplinary research uniting engineers, chemists biologists and respiratory physicians. In this review we will focus on in vivo data available to facilitate the design of nanocarrier-based strategies using NPs to modulate pulmonary immune responses.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language