Quantifying nanoparticle cellular uptake: which method is best?
- Drasler, Barbara Adolphe Merkle Institute, University of Fribourg, Switzerland
- Vanhecke, Dimitri Adolphe Merkle Institute, University of Fribourg, Switzerland
- Rodriguez-Lorenzo, Laura Adolphe Merkle Institute, University of Fribourg, Switzerland
- Petri-Fink, Alke Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland
- Rothen-Rutishauser, Barbara Adolphe Merkle Institute, University of Fribourg, Switzerland
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27.04.2017
Published in:
- Nanomedicine. - 2017, vol. 12, no. 10, p. 1095–1099
English
As the range of engineered nanoparticles (NPs) designed as specific carriers increases, for example for cell targeting and drug delivery, the question on how many NPs are interacting or are taken up by cells is becoming increasingly important for any potential biomedical application. On one hand, the delivered dose of such NPs to the targeted cells is a key parameter in the assessment of their efficiency to perform the desired action (e.g., deliver the therapeutic substance or induce a specific effect), on the other hand, the assessment of intracellular NPs is crucial also from the safety aspect as NPs might come unintentionally in contact by untargeted cells. Particularly from the regulative perspective, it is important that reproducible and reliable analytical methods for the intracellular quantification of NPs are available at an early stage in the development in order to correlate the cell burden of NPs with their possible effects at a cellular level.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 288912
- DOI 10.2217/nnm-2017-0071
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305466
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