Journal article

Roles of mitophagy in cellular physiology and development

  • Dengjel, Jörn Department of Dermatology, Medical Center, FRIAS, ZBSA Center for Biological Systems AnalysisUniversity of Freiburg, Germany -
  • Abeliovich, Hagai FRIAS, ZBSA Center for Biological Systems AnalysisUniversity of Freiburg, Germany - Department of Biochemistry and Food Science, Hebrew University of Jerusalem, Israel
Published in:
  • Cell and Tissue Research. - 2017, vol. 367, no. 1, p. 95–109
English The autophagic degradation of mitochondria, or mitophagy, has been shown to occur in eukaryotic cells under various physiological conditions. Broadly, these fall into two categories: quality-control related mitophagy and developmentally induced mitophagy. Quality-control related mitophagy, which is the lysosomal/vacuolar degradation of malfunctioning or superfluous mitochondria, is an important housekeeping function in respiring eukaryotic cells. It plays an essential role in physiological homeostasis and its deregulation has been linked to the progression of late-onset diseases. On the other hand, developmental processes such as reticulocyte maturation have also been shown to involve mitophagy. Importantly, there are clear differences between these processes. Unlike our knowledge of the more general degradation of soluble cytosolic content during starvation-induced macroautophagy, the mechanisms involved in the selective autophagic degradation of mitochondria have only recently begun to receive significant attention. Here, we review the current literature on these topics and proceed to provide specific examples from yeast and mammalian systems. Finally, we cover experimental approaches, with a focus on proteomic methods dedicated to the study of mitophagy in different systems.
Faculté des sciences et de médecine
Département de Biologie
  • English
Biological sciences
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