High prevalence of carbapenemase-producing enterobacteriaceae among hospitalized children in luanda, angola

Kieffer, Nicolas; Nordmann, Patrice; Aires-de-Sousa, Marta; Poirel, Laurent

doi:10.1128/AAC.01201-16

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Journal article

High prevalence of carbapenemase-producing enterobacteriaceae among hospitalized children in luanda, angola

Kieffer, Nicolas Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA, Paris, France), University of Fribourg, Switzerland
Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA, Paris, France), University of Fribourg, Switzerland - University of Lausanne and University Hospital Center, Lausanne, Switzerland
Aires-de-Sousa, Marta Escola Superior de Saúde da Cruz Vermelha Portuguesa (ESSCVP), Lisbon, Portugal
Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland

10.01.2016

Published in:

Antimicrobial Agents and Chemotherapy. - 2016, vol. 60, no. 10, p. 6189–6192

English This study aimed to evaluate the prevalence of carbapenemase-producing Enterobacteriaceae in Luanda, Angola. A total of 157 rectal samples were collected from children visiting a pediatric hospital in Luanda in March 2015. Fifty-seven imipenem-nonsusceptible enterobacterial isolates were recovered, most of which were non-clonally related. The blaOXA-181 (50/57) and blaNDM-1 (7/57) carbapenemase genes were identified. Notably, OXA-181-producing Escherichia coli isolates rarely coproduced extended-spectrum β-lactamases and consequently remained susceptible to broad-spectrum cephalosporins. The blaOXA-181 gene was always located on an IncX3 plasmid, while the blaNDM-1 gene was located on either IncFIA or IncA/C plasmids. The study identified a high prevalence of OXA-181 among hospitalized children in Angola.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language