REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
- Chavan, Rohit Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
- Preitner, Nadia Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Switzerland
- Okabe, Takashi Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
- Mansencal Strittmatter, Laureen Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
- Xu, Cheng Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Switzerland
- Ripperger, Jürgen A. Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
- Pitteloud, Nelly Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Switzerland
- Albrecht, Urs Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
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15.01.2017
Published in:
- Biology Open. - 2017, vol. 6, no. 1, p. 1–7
English
The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 288517
- DOI 10.1242/bio.021519
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305336
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