Journal article

REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6

  • Chavan, Rohit Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Preitner, Nadia Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Switzerland
  • Okabe, Takashi Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Mansencal Strittmatter, Laureen Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Xu, Cheng Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Switzerland
  • Ripperger, Jürgen A. Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Pitteloud, Nelly Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Switzerland
  • Albrecht, Urs Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
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    15.01.2017
Published in:
  • Biology Open. - 2017, vol. 6, no. 1, p. 1–7
English The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/305336
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