Journal article
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Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue
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Duteil, Delphine
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany
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Tosic, Milica
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany
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Lausecker, Franziska
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany
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Nenseth, Hatice Z.
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany
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Müller, Judith M.
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany
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Urban, Sylvia
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany
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Willmann, Dominica
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany
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Petroll, Kerstin
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany - Center for Biological Systems Analysis, Freiburg, Germany
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Messaddeq, Nadia
IGBMC, Department of Functional Genomics and Cancer, Université de Strasbourg, Illkirch, France
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Arrigoni, Laura
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
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Manke, Thomas
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
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Kornfeld, Jan-Wilhelm
Max Planck Institute for Metabolism Research, Cologne, Germany
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Brüning, Jens C.
Max Planck Institute for Metabolism Research, Cologne, Germany
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Zagoriy, Vyacheslav
metaSysX GmbH, Am Mühlenberg 11, Potsdam-Golm, Germany
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Meret, Michael
metaSysX GmbH, Am Mühlenberg 11, Potsdam-Golm, Germany
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Dengjel, Jörn
Department of Biology, Université de Fribourg, Switzerland
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Kanouni, Toufike
Celgene Quanticel Research, San Diego, CA 92121, USA
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Schüle, Roland
Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Germany - BIOSS Centre of Biological Signalling Studies, Freiburg, Germany - Deutsches Konsortium für Translationale Krebsforschung (DKTK), Standort Freiburg, Germany -
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Published in:
- Cell Reports. - 2016, vol. 17, no. 4, p. 1008–1021
English
Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT- selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and upregulation of white adipose tissue (WAT)-selective gene expression. This results in the accumulation of di- and triacylglycerides and culminates in a profound whitening of BAT in aged Lsd1- deficient mice. Further studies show that Lsd1 maintains BAT properties via a dual role. It activates BAT-selective gene expression in concert with the transcription factor Nrf1 and represses WAT-selective genes through recruitment of the CoREST complex. In conclusion, our data uncover Lsd1 as a key regulator of gene expression and metabolic function in BAT.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Biologie
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/305271
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