Journal article
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Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria
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Mantel, Pierre-Yves
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA - Department ofMedicine, Unit of Anatomy, University of Fribourg, Switzerland
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Hjelmqvist, Daisy
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Walch, Michael
Department ofMedicine, Unit of Anatomy, University of Fribourg, Switzerland
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Kharoubi-Hess, Solange
Department ofMedicine, Unit of Anatomy, University of Fribourg, Switzerland
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Nilsson, Sandra
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Ravel, Deepali
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Ribeiro, Marina
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Grüring, Christof
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Ma, Siyuan
Department of Biostatistics, Harvard T.H. Chan School of Public Health,Boston, USA
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Padmanabhan, Prasad
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Trachtenberg, Alexander
Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, USA
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Ankarklev, Johan
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Brancucci, Nicolas M.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA - Wellcome Trust Center for Molecular Parasitology, University of Glasgow, UK
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Huttenhower, Curtis
Department of Biostatistics, Harvard T.H. Chan School of Public Health,Boston, USA
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Duraisingh, Manoj T.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA
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Ghiran, Ionita
Division of Allergy and Infection, Beth Israel Deaconess Medical Center, Boston, USA
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Kuo, Winston P.
Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, USA - Predicine, Inc., Hayward, California, USA
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Filgueira, Luis
Department ofMedicine, Unit of Anatomy, University of Fribourg, Switzerland
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Martinelli, Roberta
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, USA
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Marti, Matthias
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, USA - Wellcome Trust Center for Molecular Parasitology, University of Glasgow, UK
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Published in:
- Nature Communications. - 2016, vol. 7, p. 12727
English
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory responses, parasite sequestration in tissues and vascular dysfunction. Production of pro-inflammatory cytokines and chemokines promotes endothelial activation as well as recruitment and infiltration of inflammatory cells, which in turn triggers further endothelial cell activation and parasite sequestration. Inflammatory responses are triggered in part by bioactive parasite products such as hemozoin and infected red blood cell-derived extracellular vesicles (iRBC-derived EVs). Here we demonstrate that such EVs contain functional miRNA-Argonaute 2 complexes that are derived from the host RBC. Moreover, we show that EVs are efficiently internalized by endothelial cells, where the miRNA-Argonaute 2 complexes modulate target gene expression and barrier properties. Altogether, these findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Médecine
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/305212
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