Liposome‐containing mechanoresponsive hydrogels
- Stalder, Etienne University of Fribourg, Department of Chemistry, Switzerland
- Zumbuehl, Andreas University of Fribourg, Department of Chemistry, Switzerland
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01.01.2017
Published in:
- Macromolecular Materials and Engineering. - 2017, vol. 302, no. 5, p. 1600549
English
The direct injection of a drug into a joint can relieve osteoarthritic pain for a short period of time. The problem is that the drug will not stay at the allocated location. Therefore, a proof-of-concept in situ is designed forming hydrogel containing liposomes that are covalently linked to the hydrogel network. When the liposomes are filled with a cargo, the formed hydrogel is thus loaded with this cargo, too. Due to the link between the hydrogel and the liposomes, a compression or other mechanical force applied to the hydrogel will rupture the liposomes and release a small percentage of the cargo. Overall, a long-term intra-articular drug release is feasible.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 279091
- DOI 10.1002/mame.201600549
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305179
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