Vesicle origami and the influence of cholesterol on lipid packing
- Tanasescu, Radu Department of Chemistry, University of Fribourg, Switzerland
- Lanz, Martin A. Department of Chemistry, University of Fribourg, Switzerland
- Mueller, Dennis Department of Chemistry, University of Fribourg, Switzerland
- Tassler, Stephanie Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
- Ishikawa, Takashi Paul Scherrer Institute (PSI), OFLB/010 5232 Villigen PSI, Switzerland
- Reiter, Renate Department of Chemistry, University of Fribourg, Switzerland / Experimental Polymer Physics, University of Freiburg, Germany / Freiburg Centre for Interactive Materials and Bioinspired Technologies (FIT), Germany
- Brezesinski, Gerald Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
- Zumbuehl, Andreas Department of Chemistry, University of Fribourg, Switzerland
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17.05.2016
Published in:
- Langmuir. - 2016, vol. 32, no. 19, p. 4896–4903
English
The artificial phospholipid Pad-PC-Pad was analyzed in 2D (monolayers at the air/water interface) and 3D (aqueous lipid dispersions) systems. In the gel phase, the two leaflets of a Pad-PC-Pad bilayer interdigitate completely, and the hydrophobic bilayer region has a thickness comparable to the length of a single phospholipid acyl chain. This leads to a stiff membrane with no spontaneous curvature. Forced into a vesicular structure, Pad-PC-Pad has faceted geometry, and in its extreme form, tetrahedral vesicles were found as predicted a decade ago. Above the main transition temperature, a noninterdigitated Lα phase with fluid chains has been observed. The addition of cholesterol leads to a slight decrease of the main transition temperature and a gradual decrease in the transition enthalpy until the transition vanishes at 40 mol % cholesterol in the mixture. Additionally, cholesterol pulls the chains apart, and a noninterdigitated gel phase is observed. In monolayers, cholesterol has an ordering effect on liquid-expanded phases and disorders condensed phases. The wavenumbers of the methylene stretching vibration indicate the formation of a liquid- ordered phase in mixtures with 40 mol % cholesterol.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 261100
- DOI 10.1021/acs.langmuir.6b01143
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305134
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