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Vesicle origami and the influence of cholesterol on lipid packing

  • Tanasescu, Radu Department of Chemistry, University of Fribourg, Switzerland
  • Lanz, Martin A. Department of Chemistry, University of Fribourg, Switzerland
  • Mueller, Dennis Department of Chemistry, University of Fribourg, Switzerland
  • Tassler, Stephanie Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
  • Ishikawa, Takashi Paul Scherrer Institute (PSI), OFLB/010 5232 Villigen PSI, Switzerland
  • Reiter, Renate Department of Chemistry, University of Fribourg, Switzerland / Experimental Polymer Physics, University of Freiburg, Germany / Freiburg Centre for Interactive Materials and Bioinspired Technologies (FIT), Germany
  • Brezesinski, Gerald Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
  • Zumbuehl, Andreas Department of Chemistry, University of Fribourg, Switzerland
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    17.05.2016
Published in:
  • Langmuir. - 2016, vol. 32, no. 19, p. 4896–4903
English The artificial phospholipid Pad-PC-Pad was analyzed in 2D (monolayers at the air/water interface) and 3D (aqueous lipid dispersions) systems. In the gel phase, the two leaflets of a Pad-PC-Pad bilayer interdigitate completely, and the hydrophobic bilayer region has a thickness comparable to the length of a single phospholipid acyl chain. This leads to a stiff membrane with no spontaneous curvature. Forced into a vesicular structure, Pad-PC-Pad has faceted geometry, and in its extreme form, tetrahedral vesicles were found as predicted a decade ago. Above the main transition temperature, a noninterdigitated Lα phase with fluid chains has been observed. The addition of cholesterol leads to a slight decrease of the main transition temperature and a gradual decrease in the transition enthalpy until the transition vanishes at 40 mol % cholesterol in the mixture. Additionally, cholesterol pulls the chains apart, and a noninterdigitated gel phase is observed. In monolayers, cholesterol has an ordering effect on liquid-expanded phases and disorders condensed phases. The wavenumbers of the methylene stretching vibration indicate the formation of a liquid- ordered phase in mixtures with 40 mol % cholesterol.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/305134
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