Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae
- Abeliovich, Hagai Department of Biochemistry and Food Science, Hebrew University of Jerusalem, Israel - Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany
- Dengjel, Jörn Department of Dermatology, Medical Center, Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany - ZBSA Center for Biological Systems Analysis, University of Freiburg, Germany -
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15.04.2016
Published in:
- Biochemical Society Transactions. - 2016, vol. 44, no. 2, p. 541–545
English
The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an important housekeeping function in respiring eukaryotic cells. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy, and plays a role in physiological homoeostasis as well as in the progression of late-onset diseases. Although the mechanism of bulk degradation by macroautophagy is relatively well established, the selective autophagic degradation of mitochondria has only recently begun to receive significant attention. In this mini- review, we introduce mitophagy as a form of mitochondrial quality control and proceed to provide specific examples from yeast and mammalian systems. We then discuss the relationship of mitophagy to mitochondrial stress, and provide a broad mechanistic overview of the process with an emphasis on evolutionarily conserved pathways.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 277287
- DOI 10.1042/BST20150278
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305131
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