Journal article

Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae

  • Abeliovich, Hagai Department of Biochemistry and Food Science, Hebrew University of Jerusalem, Israel - Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany
  • Dengjel, Jörn Department of Dermatology, Medical Center, Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany - ZBSA Center for Biological Systems Analysis, University of Freiburg, Germany -
Published in:
  • Biochemical Society Transactions. - 2016, vol. 44, no. 2, p. 541–545
English The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an important housekeeping function in respiring eukaryotic cells. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy, and plays a role in physiological homoeostasis as well as in the progression of late-onset diseases. Although the mechanism of bulk degradation by macroautophagy is relatively well established, the selective autophagic degradation of mitochondria has only recently begun to receive significant attention. In this mini- review, we introduce mitophagy as a form of mitochondrial quality control and proceed to provide specific examples from yeast and mammalian systems. We then discuss the relationship of mitophagy to mitochondrial stress, and provide a broad mechanistic overview of the process with an emphasis on evolutionarily conserved pathways.
Faculté des sciences et de médecine
Département de Biologie
  • English
Biological sciences
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