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Emergence of Escherichia coli producing OXA-48 β-lactamase in the community in Switzerland

  • Zurfluh, Katrin Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Switzerland
  • Nüesch-Inderbinen, Magdalena T Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Switzerland
  • Poirel, Laurent Medical and Molecular Microbiology Unit , Dept of Medicine, University of Fribourg, Fribourg, Switzerland
  • Nordmann, Patrice Medical and Molecular Microbiology Unit , Dept of Medicine, University of Fribourg, Fribourg, Switzerland
  • Hächler, Herbert Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Switzerland
  • Stephan, Roger Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Switzerland
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    2015
Published in:
  • Antimicrobial Resistance and Infection Control. - 2016, vol. 4, p. 9
English The emergence and worldwide spread of carbapenemase-producing Enterobacteriaceae is of great concern to public health services. The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae in the community in Switzerland.Findings: One thousand and eighty-six stool samples of healthy humans (staff members of a food-processing company which were screened for the occurrence of salmonellae) were collected in September 2014. After an initial enrichment-step, carbapenemase-producing Enterobacteriaceae were isolated from the carbapenem-containing selective medium SUPERCARBA II. Grown colonies from 11 samples were screened by PCR for the presence of bla KPC, bla NDM, bla OXA-48 and bla VIM. A single OXA-48-producing Escherichia coli was detected. Phylogenetic grouping and multi-locus sequence typing (MLST) revealed that this strain belonged to D:ST38, a type which had been previously reported in the UK, France, Lebanon and Egypt.Conclusions: The results of this study show that OXA-48-producing Enterobacteriaceae have started to spread into the community in Switzerland, and a continuous monitoring is necessary to better understand their dissemination in the human population as well as in animals and the environment.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/304992
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