Acquisition of broad-spectrum cephalosporin resistance leading to colistin resistance in Klebsiella pneumoniae
- Jayol, Aurélie Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, University of Fribourg, Switzerland
- Nordmann, Patrice Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, University of Fribourg, Switzerland - HFR - Hôpital Cantonal, Fribourg, Switzerland
- Desroches, Marine Department of Virology, Bacteriology-Infect Control, Parasitology-Mycology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, Créteil, France - IAME, UMR 1137, INSERM, Paris, France
- Decousser, Jean-Winoc Department of Virology, Bacteriology-Infect Control, Parasitology-Mycology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, Créteil, France - IAME, UMR 1137, INSERM, Paris, France
- Poirel, Laurent Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, University of Fribourg, Switzerland
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05.01.2016
Published in:
- Antimicrobial Agents and Chemotherapy. - 2016, vol. 60, no. 5, p. 3199–3201
English
An extended-spectrum β-lactamase (ESBL)-producing and colistin-resistant Klebsiella pneumoniae clinical isolate was recovered from a patient who was treated with cefotaxime. This isolate harbored a blaCTX-M-15 ESBL gene that was associated with an ISEcp1 insertion sequence. Transposition of that tandem occurred within the chromosomal mgrB gene, leading to inactivation of the mgrB gene and consequently to acquired resistance to colistin. We showed here a coselection of colistin resistance as a result of a broad- spectrum cephalosporin selective pressure.
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 259483
- DOI 10.1128/AAC.00237-16
- Persistent URL
- https://folia.unifr.ch/unifr/documents/304962
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