Journal article

Genetic features of MCR-1-producing colistin-resistant Escherichia coli isolates in South Africa

  • Poirel, Laurent Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM European Unit (LEA) (INSERM, Paris, France), University of Fribourg, Switzerland
  • Kieffer, Nicolas Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
  • Brink, Adrian Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa
  • Coetze, Jennifer Department of Clinical Microbiology and Molecular Biology, Ampath National Laboratory Services, National Referral Laboratory, Centurion, South Africa
  • Jayol, Aurélie Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
  • Nordmann, Patrice Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM European Unit (LEA) (INSERM, Paris, France), University of Fribourg, Switzerland - University of Lausanne and University Hospital Center, Lausanne, Switzerland
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    07.01.2016
Published in:
  • Antimicrobial Agents and Chemotherapy. - 2016, vol. 60, no. 7, p. 4394–4397
English A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1 cassette were identified. Promoter sequences responsible for the expression of mcr-1, deduced from the precise identification of the +1 transcription start site for mcr- 1, were characterized.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/304861
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