Genetic features of MCR-1-producing colistin-resistant Escherichia coli isolates in South Africa
- Poirel, Laurent Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM European Unit (LEA) (INSERM, Paris, France), University of Fribourg, Switzerland
- Kieffer, Nicolas Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
- Brink, Adrian Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa
- Coetze, Jennifer Department of Clinical Microbiology and Molecular Biology, Ampath National Laboratory Services, National Referral Laboratory, Centurion, South Africa
- Jayol, Aurélie Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
- Nordmann, Patrice Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM European Unit (LEA) (INSERM, Paris, France), University of Fribourg, Switzerland - University of Lausanne and University Hospital Center, Lausanne, Switzerland
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07.01.2016
Published in:
- Antimicrobial Agents and Chemotherapy. - 2016, vol. 60, no. 7, p. 4394–4397
English
A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1 cassette were identified. Promoter sequences responsible for the expression of mcr-1, deduced from the precise identification of the +1 transcription start site for mcr- 1, were characterized.
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 261142
- DOI 10.1128/AAC.00444-16
- Persistent URL
- https://folia.unifr.ch/unifr/documents/304861
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