Liver-derived ketone bodies are necessary for food anticipation

Chavan, Rohit; Feillet, Céline A.; Costa, Sara S. Fonseca; Delorme, James E.; Okabe, Takashi; Ripperger, Jürgen A.; Albrecht, Urs

doi:10.1038/ncomms10580

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Liver-derived ketone bodies are necessary for food anticipation

Chavan, Rohit Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
Feillet, Céline A. Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland - Institut de Biologie Valrose, CircadianSystems Biology, /Université de Nice Sophia Antipolis, France
Costa, Sara S. Fonseca Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
Delorme, James E. Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland - Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, USA
Okabe, Takashi Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
Ripperger, Jürgen A. Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
Albrecht, Urs Department of Biology, Unit of Biochemistry, University of Fribourg, Switzerland

03.02.2016

Published in:

Nature Communications. - 2016, vol. 7, p. 10580

English The circadian system has endowed animals with the ability to anticipate recurring food availability at particular times of day. As daily food anticipation (FA) is independent of the suprachiasmatic nuclei, the central pacemaker of the circadian system, questions arise of where FA signals originate and what role components of the circadian clock might play. Here we show that liver-specific deletion of Per2 in mice abolishes FA, an effect that is rescued by viral overexpression of Per2 in the liver. RNA sequencing indicates that Per2 regulates β-hydroxybutyrate (βOHB) production to induce FA leading to the conclusion that liver Per2 is important for this process. Unexpectedly, we show that FA originates in the liver and not in the brain. However, manifestation of FA involves processing of the liver-derived βOHB signal in the brain, indicating that the food-entrainable oscillator is not located in a single tissue but is of systemic nature.

Faculty

Faculté des sciences et de médecine

Department

Département de Biologie

Language