Single breath-hold 3D measurement of left atrial volume using compressed sensing cardiovascular magnetic resonance and a non-model-based reconstruction approach

Vardoulis, Orestis; Monney, Pierre; Bermano, Amit; Vaxman, Amir; Gotsman, Craig; Schwitter, Janine; Stuber, Matthias; Stergiopulos, Nikolaos; Schwitter, Juerg

doi:10.1186/s12968-015-0147-8

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Journal article

Single breath-hold 3D measurement of left atrial volume using compressed sensing cardiovascular magnetic resonance and a non-model-based reconstruction approach

Vardoulis, Orestis Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Swiss Federal Institute of Technology, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Monney, Pierre Division of Cardiology and Cardiac MR Center, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
Bermano, Amit Computer Graphics lab, ETH Zurich & Disney Research Zurich, Switzerland
Vaxman, Amir Geometric Modeling and Industrial Geometry group, Vienna University of Technology, Vienna, Austria
Gotsman, Craig Jacobs Technion-Cornell Institute at Cornell Tech, New York, USA
Schwitter, Janine University of Fribourg, Biomedical Sciences, Fribourg, Switzerland
Stuber, Matthias Department of Radiology, University Hospital and University of Lausanne, Switzerland - Center for Biomedical Imaging, Lausanne, Switzerland
Stergiopulos, Nikolaos Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Swiss Federal Institute of Technology, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Schwitter, Juerg Division of Cardiology and Cardiac MR Center, University Hospital of Lausanne (CHUV), Lausanne, Switzerland

11.06.2015

Published in:

Journal of Cardiovascular Magnetic Resonance. - 2015, vol. 17, no. 1, p. 47

English Background:Left atrial (LA) dilatation is associated with a large variety of cardiac diseases. Current cardiovascular magnetic resonance (CMR) strategies to measure LA volumes are based on multi-breath-hold multi-slice acquisitions, which are time-consuming and susceptible to misregistration.Aim:To develop a time-efficient single breath-hold 3D CMR acquisition and reconstruction method to precisely measure LA volumes and function.Methods:A highly accelerated compressed-sensing multi-slice cine sequence (CS-cineCMR) was combined with a non-model-based 3D reconstruction method to measure LA volumes with high temporal and spatial resolution during a single breath-hold. This approach was validated in LA phantoms of different shapes and applied in 3 patients. In addition, the influence of slice orientations on accuracy was evaluated in the LA phantoms for the new approach in comparison with a conventional model-based biplane area-length reconstruction. As a reference in patients, a self-navigated high-resolution whole-heart 3D dataset (3D-HR-CMR) was acquired during mid-diastole to yield accurate LA volumes.Results:Phantom studies. LA volumes were accurately measured by CS-cineCMR with a mean difference of −4.73 ± 1.75 ml (−8.67 ± 3.54 %, r² = 0.94). For the new method the calculated volumes were not significantly different when different orientations of the CS-cineCMR slices were applied to cover the LA phantoms. Long-axis “aligned” vs “not aligned” with the phantom long-axis yielded similar differences vs the reference volume (−4.87 ± 1.73 ml vs −4.45 ± 1.97 ml, p = 0.67) and short-axis “perpendicular” vs “not-perpendicular” with the LA long-axis (−4.72 ± 1.66 ml vs −4.75 ± 2.13 ml; p = 0.98). The conventional bi-plane area-length method was susceptible for slice orientations (p = 0.0085 for the interaction of “slice orientation” and “reconstruction technique”, 2-way ANOVA for repeated measures). To use the 3D-HR-CMR as the reference for LA volumes in patients, it was validated in the LA phantoms (mean difference: −1.37 ± 1.35 ml, −2.38 ± 2.44 %, r² = 0.97). Patient study: The CS-cineCMR LA volumes of the mid-diastolic frame matched closely with the reference LA volume (measured by 3D-HR-CMR) with a difference of −2.66 ± 6.5 ml (3.0 % underestimation; true LA volumes: 63 ml, 62 ml, and 395 ml). Finally, a high intra- and inter-observer agreement for maximal and minimal LA volume measurement is also shown.Conclusions:The proposed method combines a highly accelerated single-breathhold compressed-sensing multi-slice CMR technique with a non-model-based 3D reconstruction to accurately and reproducibly measure LA volumes and function.

Faculty

Faculté des sciences et de médecine

Department

Département de Médecine

Language