Journal article

Single breath-hold 3D measurement of left atrial volume using compressed sensing cardiovascular magnetic resonance and a non-model-based reconstruction approach

  • Vardoulis, Orestis Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Swiss Federal Institute of Technology, Ecole Polytechnique Fédérale de Lausanne, Switzerland
  • Monney, Pierre Division of Cardiology and Cardiac MR Center, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
  • Bermano, Amit Computer Graphics lab, ETH Zurich & Disney Research Zurich, Switzerland
  • Vaxman, Amir Geometric Modeling and Industrial Geometry group, Vienna University of Technology, Vienna, Austria
  • Gotsman, Craig Jacobs Technion-Cornell Institute at Cornell Tech, New York, USA
  • Schwitter, Janine University of Fribourg, Biomedical Sciences, Fribourg, Switzerland
  • Stuber, Matthias Department of Radiology, University Hospital and University of Lausanne, Switzerland - Center for Biomedical Imaging, Lausanne, Switzerland
  • Stergiopulos, Nikolaos Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Swiss Federal Institute of Technology, Ecole Polytechnique Fédérale de Lausanne, Switzerland
  • Schwitter, Juerg Division of Cardiology and Cardiac MR Center, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
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    11.06.2015
Published in:
  • Journal of Cardiovascular Magnetic Resonance. - 2015, vol. 17, no. 1, p. 47
English Background:Left atrial (LA) dilatation is associated with a large variety of cardiac diseases. Current cardiovascular magnetic resonance (CMR) strategies to measure LA volumes are based on multi-breath-hold multi-slice acquisitions, which are time-consuming and susceptible to misregistration.Aim:To develop a time-efficient single breath-hold 3D CMR acquisition and reconstruction method to precisely measure LA volumes and function.Methods:A highly accelerated compressed-sensing multi-slice cine sequence (CS-cineCMR) was combined with a non-model-based 3D reconstruction method to measure LA volumes with high temporal and spatial resolution during a single breath-hold. This approach was validated in LA phantoms of different shapes and applied in 3 patients. In addition, the influence of slice orientations on accuracy was evaluated in the LA phantoms for the new approach in comparison with a conventional model-based biplane area-length reconstruction. As a reference in patients, a self-navigated high-resolution whole-heart 3D dataset (3D-HR-CMR) was acquired during mid-diastole to yield accurate LA volumes.Results:Phantom studies. LA volumes were accurately measured by CS-cineCMR with a mean difference of −4.73 ± 1.75 ml (−8.67 ± 3.54 %, r² = 0.94). For the new method the calculated volumes were not significantly different when different orientations of the CS-cineCMR slices were applied to cover the LA phantoms. Long-axis “aligned” vs “not aligned” with the phantom long-axis yielded similar differences vs the reference volume (−4.87 ± 1.73 ml vs −4.45 ± 1.97 ml, p = 0.67) and short-axis “perpendicular” vs “not-perpendicular” with the LA long-axis (−4.72 ± 1.66 ml vs −4.75 ± 2.13 ml; p = 0.98). The conventional bi-plane area-length method was susceptible for slice orientations (p = 0.0085 for the interaction of “slice orientation” and “reconstruction technique”, 2-way ANOVA for repeated measures). To use the 3D-HR-CMR as the reference for LA volumes in patients, it was validated in the LA phantoms (mean difference: −1.37 ± 1.35 ml, −2.38 ± 2.44 %, r² = 0.97). Patient study: The CS-cineCMR LA volumes of the mid-diastolic frame matched closely with the reference LA volume (measured by 3D-HR-CMR) with a difference of −2.66 ± 6.5 ml (3.0 % underestimation; true LA volumes: 63 ml, 62 ml, and 395 ml). Finally, a high intra- and inter-observer agreement for maximal and minimal LA volume measurement is also shown.Conclusions:The proposed method combines a highly accelerated single-breathhold compressed-sensing multi-slice CMR technique with a non-model-based 3D reconstruction to accurately and reproducibly measure LA volumes and function.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/304555
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