Subsurface ablation of atherosclerotic plaque using ultrafast laser pulses
- Lanvin, Thomas Optics Laboratory, École Polytechnique Fédérale de Lausanne, Switzerland
- Conkey, Donald B. Optics Laboratory, École Polytechnique Fédérale de Lausanne, Switzerland
- Frobert, Aurélien Cardiology, Department of Medicine, University of Fribourg, Switzerland
- Valentin, Jeremy Cardiology, Department of Medicine, University of Fribourg, Switzerland
- Goy, Jean-Jacques Cardiology, Department of Medicine, University of Fribourg, Switzerland
- Cook, Stéphane Cardiology, Department of Medicine, University of Fribourg, Switzerland
- Giraud, Marie-Noëlle Cardiology, Department of Medicine, University of Fribourg, Switzerland
- Psaltis, Demetri Optics Laboratory, École Polytechnique Fédérale de Lausanne, Switzerland
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01.07.2015
Published in:
- Biomedical Optics Express. - 2015, vol. 6, no. 7, p. 2552
English
We perform subsurface ablation of atherosclerotic plaque using ultrafast pulses. Excised mouse aortas containing atherosclerotic plaque were ablated with ultrafast near-infrared (NIR) laser pulses. Optical coherence tomography (OCT) was used to observe the ablation result, while the physical damage was inspected in histological sections. We characterize the effects of incident pulse energy on surface damage, ablation hole size, and filament propagation. We find that it is possible to ablate plaque just below the surface without causing surface damage, which motivates further investigation of ultrafast ablation for subsurface atherosclerotic plaque removal.
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 257260
- DOI 10.1364/BOE.6.002552
- Persistent URL
- https://folia.unifr.ch/unifr/documents/304547
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