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Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana

  • Ndongo, Joseph T. Department of Chemistry, Higher Teacher Training College, University of Yaoundé, Cameroon
  • Issa, Mark E. School of Pharmaceutical Sciences, University of Geneva, Switzerland
  • Messi, Angelique N. Department of Organic Chemistry, Faculty of Science, University of Yaoundé, Cameroon
  • Mbing, Joséphine Ngo Department of Organic Chemistry, Faculty of Science, University of Yaoundé, Cameroon
  • Cuendet, Muriel School of Pharmaceutical Sciences, University of Geneva, Switzerland
  • Pegnyemb, Dieudonné Emmanuel School of Pharmaceutical Sciences, University of Geneva, Switzerland - Department of Organic Chemistry, Faculty of Science, University of Yaoundé, Cameroon
  • Bochet, Christian G. Department of Chemistry, University of Fribourg, Switzerland
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    02.09.2015
Published in:
  • Natural Product Research. - 2015, vol. 29, no. 17, p. 1684-1687
English Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3′,4′-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D- fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Therapeutic, pharmacy, pharmacology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/304467
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