Bilayer Properties of 1,3-Diamidophospholipids

Weinberger, Andreas; Tanasescu, Radu; Stefaniu, Cristina; Fedotenko, lllya A.; Favarger, France; Ishikawa, Takashi; Brezesinski, Gerald; Marques, Carlos M.; Zumbuehl, Andreas

doi:10.1021/la5041745

Back

Journal article

+ 1 other files

Bilayer Properties of 1,3-Diamidophospholipids

Weinberger, Andreas Department of Chemistry, University of Fribourg, Switzerland
Tanasescu, Radu Department of Chemistry, University of Fribourg, Switzerland
Stefaniu, Cristina Max Planck Institute of Colloids and Interfaces, Research Campus Potsdam-Golm, Germany
Fedotenko, lllya A. Department of Organic Chemistry, University of Geneva, Switzerland
Favarger, France Department of Organic Chemistry, University of Geneva, Switzerland
Ishikawa, Takashi Paul Scherrer Institute (PSI), Villigen PSI, Switzerland
Brezesinski, Gerald Max Planck Institute of Colloids and Interfaces, Research Campus Potsdam-Golm, Germany
Marques, Carlos M. Institut Charles Sadron (CNRS-UPR 22), Université de Strasbourg, France
Zumbuehl, Andreas Department of Chemistry, University of Fribourg, Switzerland - National Center of Competence in Research in Chemical Biology, Geneva, Switzerland

17.02.2015

Published in:

Langmuir. - 2015, vol. 31, no. 6, p. 1879–1884

English A series of 1,3-diamido phosphocholines was synthesized, and their potential to form stable bilayers was investigated. Large and giant unilamellar vesicles produced from these new lipids form a wide variety of faceted liposomes. Factors such as cooling rates and the careful choice of the liposome preparation method influence the formation of facets. Interdigitation was hypothesized as a main factor for the stabilization of facets and effectively monitored by small-angle X-ray scattering measurements.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language