Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering
-
Balog, Sandor
Adolphe Merkle Institute, University of Fribourg, Switzerland
-
Rodriguez-Lorenzo, Laura
Adolphe Merkle Institute, University of Fribourg, Switzerland
-
Monnier, Christophe A.
Adolphe Merkle Institute, University of Fribourg, Switzerland
-
Obiols-Rabas, Marc
Adolphe Merkle Institute, University of Fribourg, Switzerland - Physical Chemistry, Department of Chemistry, Lund University, Sweden
-
Rothen-Rutishauser, Barbara
Adolphe Merkle Institute, University of Fribourg, Switzerland
-
Schurtenberger, Peter
Physical Chemistry, Department of Chemistry, Lund University, Sweden
-
Petri-Fink, Alke
Adolphe Merkle Institute, University of Fribourg, Switzerland
Show more…
Published in:
- Nanoscale. - 2015, vol. 7, no. 14, p. 5991-5997
English
Light scattering is one of the few techniques available to adequately characterize suspended nanoparticles (NPs) in real time and in situ. However, when it comes to NPs in multicomponent and optically complex aqueous matrices – such as biological media and physiological fluids – light scattering suffers from lack of selectivity, as distinguishing the relevant optical signals from the irrelevant ones is very challenging. We meet this challenge by building on depolarized scattering: Unwanted signals from the matrix are completely suppressed. This approach yields information with an unprecedented signal-to-noise ratio in favour of the NPs and NP-biomolecule corona complexes, which in turn opens the frontier to scattering-based studies addressing the behaviour of NPs in complex physiological/biological fluids.
-
Faculty
- Faculté des sciences et de médecine
-
Department
- Département de Chimie
-
Language
-
-
Classification
-
Physics
-
License
-
License undefined
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/unifr/documents/304188
Statistics
Document views: 35
File downloads: