Journal article

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Polyvinyl alcohol as a biocompatible alternative for the passivation of gold nanorods

  • Kinnear, Calum Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
  • Burnand, David Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
  • Clift, Martin J. D. Adolphe Merkle Institut, Universität Freiburg, Switzerland
  • Kilbinger, Andreas F. M. Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
  • Rothen-Rutishauser, Barbara Adolphe Merkle Institut, Universität Freiburg, Switzerland
  • Petri-Fink, Alke Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
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    2014
Published in:
  • Angewandte Chemie International Edition. - 2014, vol. 53, no. 46, p. 12613–12617
English The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor, polyvinyl acetate, which is then transformed into its hydrophilic analogue, polyvinyl alcohol. This polymer was chosen due to its well-established biocompatibility, tunable “stealth” properties, tunable hydrophobicity, and high degree of functionality. The biocompatibility of the functionalized GNRs was tested by exposing them to primary human blood monocyte derived macrophages; the advantages of tunable hydrophobicity were demonstrated with the long-term stable encapsulation of a model hydrophobic drug molecule.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/304152
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