Polyvinyl alcohol as a biocompatible alternative for the passivation of gold nanorods
- Kinnear, Calum Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
- Burnand, David Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
- Clift, Martin J. D. Adolphe Merkle Institut, Universität Freiburg, Switzerland
- Kilbinger, Andreas F. M. Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
- Rothen-Rutishauser, Barbara Adolphe Merkle Institut, Universität Freiburg, Switzerland
- Petri-Fink, Alke Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
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2014
Published in:
- Angewandte Chemie International Edition. - 2014, vol. 53, no. 46, p. 12613–12617
English
The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor, polyvinyl acetate, which is then transformed into its hydrophilic analogue, polyvinyl alcohol. This polymer was chosen due to its well-established biocompatibility, tunable “stealth” properties, tunable hydrophobicity, and high degree of functionality. The biocompatibility of the functionalized GNRs was tested by exposing them to primary human blood monocyte derived macrophages; the advantages of tunable hydrophobicity were demonstrated with the long-term stable encapsulation of a model hydrophobic drug molecule.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
-
- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 234226
- DOI 10.1002/anie.201404100
- Persistent URL
- https://folia.unifr.ch/unifr/documents/304152
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