Journal article

Sensory determinants of behavioral dynamics in Drosophila thermotaxis

  • Klein, Mason Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA
  • Afonso, Bruno Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA - Janelia Farm Research Campus, Ashburn, VA, USA
  • Vonner, Ashley J. Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA
  • Hernandez-Nunez, Luis Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA
  • Berck, Matthew Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA
  • Tabone, Christopher J. Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA
  • Kane, Elizabeth A. Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA
  • Pieribone, Vincent A. Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA - The John B. Pierce Laboratory, Inc., New Haven, CT, USA
  • Nitabach, Michael N. Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA - Department of Genetics and fProgram in Cellular Neuroscience, Neurodegeneration, and Repair, Yale School of Medicine, New Haven, CT, USA -
  • Cardona, Albert Janelia Farm Research Campus, Ashburn, VA, USA
  • Zlatic, Marta Janelia Farm Research Campus, Ashburn, VA, USA
  • Sprecher, Simon G. Janelia Farm Research Campus, Ashburn, VA, USA - Institute of Cell and Developmental Biology, Department of Biology, University of Fribourg, Switzerland
  • Gershow, Marc Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA
  • Garrity, Paul A. Department of Biology, Brandeis University, Waltham, MA, USA
  • Samuel, Aravinthan D. T. Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA, USA - Janelia Farm Research Campus, Ashburn, VA, USA
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    13.01.2015
Published in:
  • Proceedings of the National Academy of Sciences. - 2014, vol. 112, no. 2, p. E220–E229
English Complex animal behaviors are built from dynamical relationships between sensory inputs, neuronal activity, and motor outputs in patterns with strategic value. Connecting these patterns illuminates how nervous systems compute behavior. Here, we study Drosophila larva navigation up temperature gradients toward preferred temperatures (positive thermotaxis). By tracking the movements of animals responding to fixed spatial temperature gradients or random temperature fluctuations, we calculate the sensitivity and dynamics of the conversion of thermosensory inputs into motor responses. We discover three thermosensory neurons in each dorsal organ ganglion (DOG) that are required for positive thermotaxis. Random optogenetic stimulation of the DOG thermosensory neurons evokes behavioral patterns that mimic the response to temperature variations. In vivo calcium and voltage imaging reveals that the DOG thermosensory neurons exhibit activity patterns with sensitivity and dynamics matched to the behavioral response. Temporal processing of temperature variations carried out by the DOG thermosensory neurons emerges in distinct motor responses during thermotaxis.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/304097
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