Journal article

Considering the degradation effects of amino-functional plasma polymer coatings for biomedical application

  • Hegemann, Dirk Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Hanselmann, Barbara Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Guimond, Sébastien Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Fortunato, Giuseppino Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Giraud, Marie-Noëlle Cardiology, University of Fribourg, Switzerland
  • Guex, Anne Géraldine Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
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    25.09.2014
Published in:
  • Surface and Coatings Technology. - 2014, vol. 255, p. 90–95
English Materials for biomedical applications typically involve surface engineering. Scaffolds used for tissue engineering, for example, require a surface functionalization in order to support cell growth. The deposition of functional plasma polymer coatings seems to be an attractive approach to modify substrates for biomedical applications.Possible degradation of highly functional plasma polymers and the effect of its degradation products on cell growth, however, are not yet investigated in detail. Plasma polymer formation is governed by gas phase (mainly determining the chemical composition) and surface processes (inducing cross-linking) which both influence the incorporation of amino groups in a-C:H:N coatings deposited by NH₃/C₂H₄ discharges. Aging is studied in air and in aqueous conditions revealing the degradation of such plasma polymers (loss in thickness and loss of amino groups). Degradation products seem to influence viability and proliferation of mouse skeletal muscle cells on electrospun poly(ε-caprolactone) scaffolds. Thus, possible chemical changes as a function of time or exposure to different media must be taken into account in the design of functional plasma polymer coatings for biomedical applications in order to avoid possible adverse effects on cell growth.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/303946
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