The difficult-to-control spread of carbapenemase producers in Enterobacteriaceae worldwide

Nordmann, Patrice; Poirel, Laurent

doi:10.1111/1469-0691.12719

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Journal article

The difficult-to-control spread of carbapenemase producers in Enterobacteriaceae worldwide

Nordmann, Patrice Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - Hôpital Fribourgeois – Hôpital Cantonal de Fribourg, Switzerland - INSERM U914, South-Paris Medical School, K.-Bicêtre, France
Poirel, Laurent Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM U914, South-Paris Medical School, K.-Bicêtre, France

01.06.2014

Published in:

Clinical Microbiology and Infection. - 2014, vol. 20, no. 9, p. 821-830

English Spread of carbapenemase producers in Enterobacteriaceae is now identified worldwide. Three main carbapenemases are reported which belong to three classes of ß-lactamases that are KPC, NDM and OXA-48. The main reservoirs of KPC are Klebsiella pneumoniae in the USA, Israel, Greece and Italy, of NDM are K. pneumoniae and Escherichia coli in the Indian subcontinent, and of OXA-48 are K. pneumoniae and E. coli in North Africa and Turkey. KPC producers remain mostly identified in nosocomial isolates whereas NDM and OXA-48 producers are both nosocomial and community-acquired pathogens. Control of their spread is still possible in hospital settings and relies on the use of rapid diagnostic techniques and strict implemention of hygiene measures.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language