The difficult-to-control spread of carbapenemase producers in Enterobacteriaceae worldwide
- Nordmann, Patrice Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - Hôpital Fribourgeois – Hôpital Cantonal de Fribourg, Switzerland - INSERM U914, South-Paris Medical School, K.-Bicêtre, France
- Poirel, Laurent Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM U914, South-Paris Medical School, K.-Bicêtre, France
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01.06.2014
Published in:
- Clinical Microbiology and Infection. - 2014, vol. 20, no. 9, p. 821-830
English
Spread of carbapenemase producers in Enterobacteriaceae is now identified worldwide. Three main carbapenemases are reported which belong to three classes of ß-lactamases that are KPC, NDM and OXA-48. The main reservoirs of KPC are Klebsiella pneumoniae in the USA, Israel, Greece and Italy, of NDM are K. pneumoniae and Escherichia coli in the Indian subcontinent, and of OXA-48 are K. pneumoniae and E. coli in North Africa and Turkey. KPC producers remain mostly identified in nosocomial isolates whereas NDM and OXA-48 producers are both nosocomial and community-acquired pathogens. Control of their spread is still possible in hospital settings and relies on the use of rapid diagnostic techniques and strict implemention of hygiene measures.
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 213280
- DOI 10.1111/1469-0691.12719
- Persistent URL
- https://folia.unifr.ch/unifr/documents/303646
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