Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria

Poirel, Laurent; Savov, Encho; Nazli, Arzu; Trifonova, Angelina; Todorova, Iva; Gergova, Ivanka; Nordmann, Patrice

doi:10.1128/AAC.02571-13

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Journal article

Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria

Poirel, Laurent Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM U914, South-Paris Medical School, K.-Bicêtre, France
Savov, Encho Laboratory of Microbiology, Military Medical Academy, Sofia, Bulgaria
Nazli, Arzu Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
Trifonova, Angelina Laboratory of Microbiology, Military Medical Academy, Sofia, Bulgaria
Todorova, Iva Laboratory of Microbiology, Military Medical Academy, Sofia, Bulgaria
Gergova, Ivanka Laboratory of Microbiology, Military Medical Academy, Sofia, Bulgaria
Nordmann, Patrice Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM U914, South-Paris Medical School, K.-Bicêtre, France

04.01.2014

Published in:

Antimicrobial Agents and Chemotherapy. - 2014, vol. 58, no. 4, p. 2472–2474

English Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum-β-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB, conferring high-level resistance to all aminoglycosides. All those isolates were clonally related and belonged to the same sequence type, ST101. In addition to being the first to identify NDM-producing isolates in Bulgaria, this is the very first study reporting an outbreak of NDM-1-producing E. coli in the world.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language