Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization
- Digigow, Reinaldo G. Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland
- Dechézelles, Jean-François Adolphe Merkle Institute, University of Fribourg, Switzerland
- Kaufmann, J. CSEM Alpnach, Centre Suisse d'Electronique et de Microtechnique, Alpnach Dorf, Switzerland
- Vanhecke, Dimitri Adolphe Merkle Institute, University of Fribourg, Switzerland
- Knapp, H. CSEM Alpnach, Centre Suisse d'Electronique et de Microtechnique, Alpnach Dorf, Switzerland
- Lattuada, Marco Adolphe Merkle Institute, University of Fribourg, Switzerland
- Rothen-Rutishauser, Barbara Adolphe Merkle Institute, University of Fribourg, Switzerland
- Petri-Fink, Alke Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland
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01.01.2014
Published in:
- Lab on a Chip. - 2014, vol. 14, no. 13, p. 2276-2286
English
Microreactors have attracted wide attention in the nano- and biotechnology fields because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study of the development process in terms of setup, loading capacity and efficiency is described. We performed experimental and computational studies in order to evaluate the trapping efficiencies, maximum loading capacity and magnetic alignment of the nanoparticles. The results showed that capacity and trapping efficiencies are directly related to the flow rate, elution time and reactor type. Based on our results and the developed magnetic microreactor, we describe a model multistep surface derivatization procedure of SPIONs.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 210019
- DOI 10.1039/C4LC00229F
- Persistent URL
- https://folia.unifr.ch/unifr/documents/303485
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