Journal article

Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012

  • Dortet, Laurent INSERM U914 ‘Emerging Resistance to Antibiotics’, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France - Associated National Reference Center for Antibiotic Resistance, K.-Bicêtre, France
  • Cuzon, Gaëlle INSERM U914 ‘Emerging Resistance to Antibiotics’, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France
  • Nordmann, Patrice INSERM U914 ‘Emerging Resistance to Antibiotics’, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France - Associated National Reference Center for Antibiotic Resistance, K.-Bicêtre, France - Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland
    03.01.2014
Published in:
  • Journal of Antimicrobial Chemotherapy. - 2014, vol. 69, no. 3, p. 623-627
English Objectives: Carbapenem-resistant Enterobacteriaceae isolates (n = 1485) were received at the French Associated National Reference Center for Antibiotic Resistance in 2012 and were characterized for their mechanism of resistance to carbapenems.Methods: Carbapenemase production was detected using the biochemical-based Carba NP test, based on the detection of in vitro hydrolysis of imipenem. All isolates with a positive Carba NP test result were characterized by PCR and sequencing.Results: Carbapenemase production was identified in 23.1% of the isolates. The main carbapenemase type identified was OXA-48 and derivatives (75.5%). An overseas source was clearly demonstrated for only 27.6% of the isolates.Conclusions: OXA-48 and derivatives are now the most prevalent carbapenemases in France, with a possible spread of these producers in the community
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/303331
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