Journal article

The Brief Psychiatric Rating Scale (version 4.0) factorial structure and its sensitivity in the treatment of outpatients with unipolar depression

  • Zanello, Adriano University Department of Mental Health and Psychiatry, HUG, Geneva, Switzerland
  • Berthoud, Laurent University Institute of Psychotherapy, Department of Psychiatry, University of Lausanne, Switzerland
  • Ventura, Joseph Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA
  • Merlo, Marco C. G. Department of medicine, University of Fribourg, Switzerland
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  • Psychiatry Research. - 2013, vol. 210, no. 2, p. 626–633
English The 24-item Brief Psychiatric Rating Scale (BPRS, version4.0) enables the rater to measure psychopathology severity. Still, little is known about the BPRS's reliability and validity outside of the psychosis spectrum. The aim of this study was to examine the factorial structure and sensitivity to change of the BPRS in patients with unipolar depression. Two hundred and forty outpatients with unipolar depression were administered the 24-item BPRS. Assessments were conducted at intake and at post-treatment in a Crisis Intervention Centre. An exploratory factor analysis of the 24-item BPRS produced a six-factor solution labelled “Mood disturbance”, “Reality distortion”, “Activation”, “Apathy”, “Disorganization”, and “Somatization”. The reduction of the total BPRS score and dimensional scores, except for “Activation”, indicates that the 24-item BPRS is sensitive to change as shown in patients that appeared to have benefited from crisis treatment. The findings suggest that the 24-item BPRS could be a useful instrument to measure symptom severity and change in symptom status in outpatients presenting with unipolar depression.
Faculté des sciences et de médecine
Médecine 3ème année
  • English
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