TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice
- Heidegger, Simon Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Kirchner, Sophie-Kathrin Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Stephan, Nicolas Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Bohn, Bernadette Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Suhartha, Nina Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Hotz, Christian Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany - Chair of Pharmacology, Department of Internal Medicine, University of Fribourg, Switzerland
- Anz, David Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Sandholzer, Nadja Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Stecher, Bärbel Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, Germany
- Rüssmann, Holger Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, Germany - Helios Clinic Emil von Behring, Institute for Microbiology, Immunology and Laboratory Medicine, Berlin, Germany
- Endres, Stefan Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
- Bourquin, Carole Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Germany
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15.05.2013
Published in:
- The Journal of Immunology. - 2013, vol. 190, no. 10, p. 5313–5320
English
The trafficking of effector T cells is tightly regulated by the expression of site-specific sets of homing molecules. In contrast, naive T cells are generally assumed to express a uniform pattern of homing molecules and to follow a random distribution within the blood and secondary lymphoid organs. In this study, we demonstrate that systemic infection fundamentally modifies the trafficking of circulating naive CD8⁺ T cells. We show that on naive CD8⁺ T cells, the constitutive expression of the integrin α₄β₇ that effects their entry into GALT is downregulated following infection of mice with Salmonella typhimurium. We further show that this downregulation is dependent on TLR signaling, and that the TLR-activated naive CD8⁺ T cells are blocked from entering GALT. This contrasts strongly with Ag-experienced effector T cells, for which TLR costimulation in the GALT potently upregulates α₄β₇ and enhances trafficking to intestinal tissues. Thus, TLR activation leads to opposite effects on migration of naive and effector CD8⁺ T cells. Our data identify a mechanism that excludes noncognate CD8⁺ T cells from selected immune compartments during TLR-induced systemic inflammation.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 32020
- DOI 10.4049/jimmunol.1202280
- Persistent URL
- https://folia.unifr.ch/unifr/documents/302988
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