A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth : a randle cycle favoring fat storage
- Marcelino, Helena Department of Medicine/Physiology, University of Fribourg, Switzerland
- Veyrat-Durebex, Christelle Department of Internal Medicine, Faculty of Medicine, University of Geneva, Switzerland
- Summermatter, Serge Department of Medicine/Physiology, University of Fribourg, Switzerland
- Sarafian, Delphine Department of Medicine/Physiology, University of Fribourg, Switzerland
- Miles-Chan, Jennifer L. Department of Medicine/Physiology, University of Fribourg, Switzerland
- Arsenijevic, Denis Department of Medicine/Physiology, University of Fribourg, Switzerland
- Zani, Fabio Department of Medicine/Physiology, University of Fribourg, Switzerland
- Montani, Jean-Pierre Department of Medicine/Physiology, University of Fribourg, Switzerland
- Seydoux, Josiane Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Switzerland
- Solinas, Giovanni Department of Medicine/Physiology, University of Fribourg, Switzerland
- Rohner-Jeanrenaud, Françoise Department of Internal Medicine, Faculty of Medicine, University of Geneva, Switzerland
- Dulloo, Abdul G. Department of Medicine/Physiology, University of Fribourg, Switzerland
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06.09.2012
Published in:
- Diabetes. - 2013, vol. 62, no. 2, p. 362-372
English
Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose tissue, where de novo lipogenic capacity is concomitantly enhanced. Here we report that isocaloric refeeding on a high-fat (HF) diet blunts the enhanced in vivo insulin-dependent glucose utilization for de novo lipogenesis (DNL) in adipose tissue. These are shown to be early events of catch-up growth that are independent of hyperphagia and precede the development of overt adipocyte hypertrophy, adipose tissue inflammation, or defective insulin signaling. These results suggest a role for enhanced DNL as a glucose sink in regulating glycemia during catch-up growth, which is blunted by exposure to an HF diet, thereby contributing, together with skeletal muscle insulin resistance, to the development of glucose intolerance. Our findings are presented as an extension of the Randle cycle hypothesis, whereby the suppression of DNL constitutes a mechanism by which dietary lipids antagonize glucose utilization for storage as triglycerides in adipose tissue, thereby impairing glucose homeostasis during catch-up growth.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 31894
- DOI 10.2337/db12-0255
- Persistent URL
- https://folia.unifr.ch/unifr/documents/302965
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