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Journal article

Notch signaling in the brain: In good and bad times

  • Alberi, Lavinia Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
  • Hoey, Sarah Division of Psychiatry Research and Psychogeriatric Medicine, University of Zurich, Switzerland
  • Brai, Emanuele Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
  • Scotti, Alessandra Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland - Institute of Anatomy, University of Bern, Switzerland
  • Marathe, Swananda Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
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    06.04.2013
Published in:
  • Ageing Research Reviews. - 2013, vol. 12, no. 3, p. 801-814
Notch signaling
DSL ligands
Neuronal plasticity
Learning memory
Hypoxia ischemia
English Notch signaling is an evolutionarily conserved pathway, which is fundamental for neuronal development and specification. In the last decade, increasing evidence has pointed out an important role of this pathway beyond embryonic development, indicating that Notch also displays a critical function in the mature brain of vertebrates and invertebrates. This pathway appears to be involved in neural progenitor regulation, neuronal connectivity, synaptic plasticity and learning/memory. In addition, Notch appears to be aberrantly regulated in neurodegenerative diseases, including Alzheimer's disease and ischemic injury. The molecular mechanisms by which Notch displays these functions in the mature brain are not fully understood, but are currently the subject of intense research. In this review, we will discuss old and novel Notch targets and molecular mediators that contribute to Notch function in the mature brain and will summarize recent findings that explore the two facets of Notch signaling in brain physiology and pathology.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/302914
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