Amino covalent binding approach on iron oxide nanoparticle surface: toward biological applications

Griffete, Nébéwia; Clift, Martin J. D.; Lamouri, Aazdine; Digigow, Reinaldo G.; Mihut, Adriana M.; Petri-Fink, Alke; Rothen-Rutishauser, Barbara; Dietsch, Hervé

doi:10.1016/j.colsurfa.2012.09.020

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Journal article

Amino covalent binding approach on iron oxide nanoparticle surface: toward biological applications

Griffete, Nébéwia Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland - Department of Physics and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
Clift, Martin J. D. Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
Lamouri, Aazdine Univ. Paris Diderot, Sorbonne Paris Cite, ITODYS, Paris, France
Digigow, Reinaldo G. Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
Mihut, Adriana M. Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
Petri-Fink, Alke Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland - Department of Chemistry and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
Rothen-Rutishauser, Barbara Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland - Respiratory Medicine, Bern University Hospital, Inselspital, Switzerland
Dietsch, Hervé Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland

26.09.2012

Published in:

Colloids and Surfaces A: Physicochemical and Engineering Aspects. - 2012, vol. 415, p. 98-104

English We report on the synthesis and the surface modification of different types of magnetic iron oxide particles by developing an original process based on diazonium salts chemistry. Particles were first coated with amino groups and then subjected to polyethylene glycol (PEG) surface modification. They were subsequently characterized by Transmission electron microscopy, infrared spectroscopy, diffraction light scattering and by Zeta potential. To show the efficiency of this surface modification method, the potential cytotoxicity and (pro-)inflammatory effect of the PEG magnetic particles were also analyzed in vitro. This covalently surface modification approach based on diazonium salts chemistry provides individually dispersed, PEG-modified magnetic nanoparticles suitable for biological applications.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language