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Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation

  • Ting-A-Kee, Ryan Institute of Medical Science, University of Toronto, Canada
  • Vargas-Perez, Hector Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Canada
  • Bufalino, Mary Rose Department of Medical Biophysics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada
  • Bahi, Amine Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
  • Dreyer, Jean-Luc Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Tyndale, Rachel F. Centre for Addiction and Mental Health, Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Canada
  • Kooy, Derek van der Institute of Medical Science, University of Toronto, Canada - Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Canada - Department of Medical Biophysics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada
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    2012
Published in:
  • European Journal of Neuroscience. - 2012
English Recent work has shown that infusion of brain-derived neurotrophic factor (BDNF) into the ventral tegmental area (VTA) promotes a switch in the mechanisms mediating morphine motivation, from a dopamine-independent to a dopamine-dependent pathway. Here we showed that a single infusion of intra-VTA BDNF also promoted a switch in the mechanisms mediating ethanol motivation, from a dopamine-dependent to a dopamine-independent pathway (exactly opposite to that seen with morphine). We suggest that intra-VTA BDNF, via its actions on TrkB receptors, precipitates a switch similar to that which occurs naturally when mice transit from a drug-naive, non-deprived state to a drug-deprived state. The opposite switching of the mechanisms underlying morphine and ethanol motivation by BDNF in previously non-deprived animals is consistent with their proposed actions on VTA GABAA receptors.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/302724
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