Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation
- Ting-A-Kee, Ryan Institute of Medical Science, University of Toronto, Canada
- Vargas-Perez, Hector Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Canada
- Bufalino, Mary Rose Department of Medical Biophysics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada
- Bahi, Amine Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
- Dreyer, Jean-Luc Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
- Tyndale, Rachel F. Centre for Addiction and Mental Health, Departments of Psychiatry, Pharmacology and Toxicology, University of Toronto, Canada
- Kooy, Derek van der Institute of Medical Science, University of Toronto, Canada - Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Canada - Department of Medical Biophysics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada
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2012
Published in:
- European Journal of Neuroscience. - 2013, vol. 37, no. 6, p. 996-1003
English
Recent work has shown that infusion of brain-derived neurotrophic factor (BDNF) into the ventral tegmental area (VTA) promotes a switch in the mechanisms mediating morphine motivation, from a dopamine-independent to a dopamine-dependent pathway. Here we showed that a single infusion of intra-VTA BDNF also promoted a switch in the mechanisms mediating ethanol motivation, from a dopamine-dependent to a dopamine-independent pathway (exactly opposite to that seen with morphine). We suggest that intra-VTA BDNF, via its actions on TrkB receptors, precipitates a switch similar to that which occurs naturally when mice transit from a drug-naive, non-deprived state to a drug-deprived state. The opposite switching of the mechanisms underlying morphine and ethanol motivation by BDNF in previously non-deprived animals is consistent with their proposed actions on VTA GABAA receptors.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 31320
- DOI 10.1111/ejn.12105
- Persistent URL
- https://folia.unifr.ch/unifr/documents/302724
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