Journal article

Postnatal development of metabolic flexibility and enhanced oxidative capacity after prenatal undernutrition

  • Norman, Amy M. Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
  • Miles-Chan, Jennifer L. Institute of Physiology, Department of Medicine, University of Fribourg, Switzerland
  • Thompson, Nichola M. Discipline of Physiology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, Australia
  • Breier, Bernhard H. Institute of Food, Nutrition and Human Health, Massey University, Albany Campus, Auckland, New Zealand
  • Huber, Korinna Department of Physiology, University of Veterinary Medicine, Hannover, Germany
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Published in:
  • Reproductive Sciences. - 2012, vol. 19, no. 6, p. 607-614
English Metabolic flexibility is the body’s ability to adapt to changing energy demand and nutrient supply. Maternal undernutrition causes growth restriction at birth and subsequent obesity development. Intriguingly, metabolic flexibility is maintained due to adaptations of muscle tissue. The aim of the present study was to investigate developmental pathways of these adaptive changes. Wistar rats received standard chow at either ad libitum (AD) or 30% of ad libitum intake (UN) throughout pregnancy. At all ages, metabolic status indicated similar insulin sensitivity in AD and UN offspring despite the development of adiposity in UN offspring at weaning. Type IIA fiber size was reduced in soleus muscle of UN offspring at weaning and they had a higher percentage of type I fibers in adulthood with a concomitantly higher oxidative capacity. Plasticity of muscle was present during the postnatal period and proposes novel pathways for the dynamic development of metabolic flexibility throughout postnatal life.
Faculté des sciences et de médecine
Département de Médecine
  • English
Biological sciences
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