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Inter- and intrahemispheric dissociations in ideomotor apraxia : a large-Scale lesion–symptom mapping study in subacute brain-damaged patients

  • Manuel, Aurelie L. Department of Clinical Neurosciences, Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center and University of Lausanne, Switzerland
  • Radman, Narges Department of Medicine, Neurology Unit, University of Fribourg, Switzerland
  • Mesot, Delphine Department of Clinical Neurosciences, Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center and University of Lausanne, Switzerland
  • Chouiter, Leila Department of Medicine, Neurology Unit, University of Fribourg, Switzerland
  • Clarke, Stephanie Department of Clinical Neurosciences, Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center and University of Lausanne, Switzerland
  • Annoni, Jean-Marie Department of Medicine, Neurology Unit, University of Fribourg, Switzerland
  • Spierer, Lucas Department of Clinical Neurosciences, Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center and University of Lausanne, Switzerland
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    2012
Published in:
  • Cerebral Cortex. - 2012, vol. 23, no. 12, p. 2781-2789
Frontal
Ideomotor apraxia
Lesion
Pantomime
Parietal
Voxel-based lesion-symptom mapping
English Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior frontal areas, suggesting that defective selection of movement features is the cause of pantomime errors. We conducted a large-scale voxel-based lesion–symptom mapping analyses with configural/spatial (CS) and body-part-as-object (BPO) pantomime errors of 150 left and right brain-damaged patients. Our results confirm the left hemisphere dominance in pantomime. Both types of error were associated with damage to left inferior frontal regions in tumor and stroke patients. While CS pantomime errors were associated with left temporoparietal lesions in both stroke and tumor patients, these errors appeared less associated with parietal areas in stroke than in tumor patients and less associated with temporal in tumor than stroke patients. BPO errors were associated with left inferior frontal lesions in both tumor and stroke patients. Collectively, our results reveal a left intrahemispheric dissociation for various aspects of pantomime, but with an unspecific role for inferior frontal regions.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/302568
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