Perspectives of targeting mTORC1–S6K1 in cardiovascular aging
- Ming, Xiu-Fen Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
- Montani, Jean-Pierre Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
- Yang, Zhihong Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
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25.01.2012
Published in:
- Frontiers in Vascular Physiology. - 2012, vol. 3, p. 5
English
The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in mammalian lifespan regulation and age-related diseases such as type II diabetes mellitus and cancer. The role of mTORC1–S6K1 in age-related cardiovascular diseases is, however, largely unknown and the available experimental results are controversial. This review article primarily summarizes the most recent advances toward understanding the role of mTORC1–S6K1 in cardiovascular aging and discusses the future perspectives of targeting mTORC1–S6K1 signaling as a healthy lifespan extension modality in anti-aging and anti-cardiovascular aging.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 29153
- DOI 10.3389/fphys.2012.00005
- Persistent URL
- https://folia.unifr.ch/unifr/documents/302482
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