In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype
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Anz, David
Centre of Integrated Protein Science Munich (CIPS-M), Division of Clinical Pharmacology, Munich, Germany - Medizinische Klinik Innenstadt, Munich, Germany
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Eiber, Stephan
Centre of Integrated Protein Science Munich (CIPS-M), Division of Clinical Pharmacology, Munich, Germany
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Scholz, Christoph
Department of Obstetrics and Gynaecology, Ludwig Maximilian University, Munich, Germany
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Endres, Stefan
Centre of Integrated Protein Science Munich (CIPS-M), Division of Clinical Pharmacology, Munich, Germany
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Kirchner, Thomas
Department of Pathology, Ludwig Maximilian University, Munich, Germany
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Bourquin, Carole
Centre of Integrated Protein Science Munich (CIPS-M), Division of Clinical Pharmacology, Munich, Germany - Department of Pharmacology, University of Fribourg, Switzerland
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Mayr, Doris
Department of Pathology, Ludwig Maximilian University, Munich, Germany
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Published in:
- Histopathology. - 2011, vol. 59, no. 5, p. 965–974
English
Aims: Medullary breast cancer (MBC) is a biologically distinct subtype of breast cancer characterized by prominent lymphocytic infiltrates and a favourable clinical outcome. Tumour-infiltrating CD8+ effector T cells may contribute to the good prognosis of this type of cancer; however, certain subtypes of lymphocyte, such as FoxP3+ regulatory T cells (Tregs), can also suppress antitumour immunity.Methods and results: We determined tumour infiltration by FoxP3+, CCL22+ and CD8+ cells in paraffin-embedded sections of MBC, and, as a reference, in samples of grade 3 ductal, lobular and mucinous breast cancer. All analysed MBCs were strongly infiltrated by FoxP3+ cells, whereas only weak infiltrates were detected in ductal or lobular breast cancer. This finding was unexpected, given the good prognosis of MBC. Strikingly, the number of CD8+ T cells exceeded the number of FoxP3+ cells in MBC (ratio of CD8+ to FoxP3+ cells of 2.6), whereas equal amounts of both cell types were found in ductal breast cancer (ratio of CD8+ to FoxP3+ cells of 1.1). In both types of breast cancer, we also detected cells expressing the Treg-attracting chemokine CCL22.Conclusions: In breast cancer, a predominance of tumour-infiltrating CD8+ over FoxP3+ cells was observed in MBC. Thus, the ratio of CD8+ to FoxP3+ cells rather than the absolute number of intratumoral FoxP3+ cells may be predictive for the clinical outcome of cancer.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Médecine
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/302450
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