The all-photochemical synthesis of an OGP(10–14) precursor
- Débieux, Jean-Luc Department of Chemistry, University of Fribourg, Switzerland
- Bochet, Christian G. Department of Chemistry, University of Fribourg, Switzerland
-
06.10.2011
Published in:
- Chemical Science. - 2012, vol. 3, no. 2, p. 405-406
English
An all-photochemical synthesis of OGP(10–14){,} the biologically active part of an osteogenic growth peptide{,} was performed. This required the preparation of photochemically activable amino acids containing a 5{,}7-dinitroindoline derivative on the C-terminus and a photolabile Ddz protecting group on the N-terminus. The photochemical acyl transfer from the dinitroindoline to an incoming nucleophilic amino group{,} which creates the amide bond{,} requires an irradiation wavelength of 385 nm. The deprotection of the Ddz group requires a shorter wavelength (300 nm){,} thus making both successive processes compatible.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 27948
- DOI 10.1039/c1sc00700a
- Persistent URL
- https://folia.unifr.ch/unifr/documents/302330
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