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The all-photochemical synthesis of an OGP(10–14) precursor

    06.10.2011
Published in:
  • Chemical Science. - 2012
English An all-photochemical synthesis of OGP(10–14){,} the biologically active part of an osteogenic growth peptide{,} was performed. This required the preparation of photochemically activable amino acids containing a 5{,}7-dinitroindoline derivative on the C-terminus and a photolabile Ddz protecting group on the N-terminus. The photochemical acyl transfer from the dinitroindoline to an incoming nucleophilic amino group{,} which creates the amide bond{,} requires an irradiation wavelength of 385 nm. The deprotection of the Ddz group requires a shorter wavelength (300 nm){,} thus making both successive processes compatible.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/302330
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