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Klf15 orchestrates circadian nitrogen homeostasis

  • Jeyaraj, Darwin Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA - Heart and Vascular Research Center MetroHealth Campus Case Western Reserve University Cleveland, USA
  • Scheer, Frank A. J. L. Division of Sleep Medicine Brigham and Women s Hospital and Harvard Medical School Boston, USA
  • Ripperger, Jürgen A. Department of Biology, Division of Biochemistry University of Fribourg, Switzerland
  • Haldar, Saptarsi M Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
  • Lu, Yuan Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
  • Prosdocimo, Domenick A. Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
  • Eapen, Sam J. Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
  • Eapen, Betty L. Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
  • Cui, Yingjie Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
  • Mahabeleshwar, Ganapathi H. Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
  • Lee, Hyoung gon Department of Pathology Western Reserve University Cleveland, USA
  • Smith, Mark A. Department of Pathology Western Reserve University Cleveland, USA
  • Casadesus, Gemma Department of Neurosciences Western Reserve University Cleveland, USA
  • Mintz, Eric M. Department of Biological Sciences Kent State University Kent, USA
  • Sun, Haipeng Department of Anesthesia UCLA Los Angeles, USA
  • Wang, Yibin Department of Anesthesia UCLA Los Angeles, USA
  • Ramsey, Kathryn M. Department of Medicine Northwestern University Feinberg School of Medicine Chicago, USA
  • Bass, Joseph Department of Medicine Northwestern University Feinberg School of Medicine Chicago, USA
  • Shea, Steven A. Division of Sleep Medicine Brigham and Women s Hospital and Harvard Medical School Boston, USA
  • Albrecht, Urs Department of Biology, Division of Biochemistry University of Fribourg, Switzerland
  • Jain, Mukesh K. Case Cardiovascular Research Institute Harrington Heart and Vascular Institute Department of Medicine Western Reserve University Cleveland, USA
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    06.03.2012
Published in:
  • Cell Metabolism. - 2012, vol. 15, no. 3, p. 311–323
English Diurnal variation in nitrogen homeostasis is observed across phylogeny. But whether these are endogenous rhythms, and if so, molecular mechanisms that link nitrogen homeostasis to the circadian clock remain unknown. Here, we provide evidence that a clock-dependent peripheral oscillator, Krüppel-like factor 15 transcriptionally coordinates rhythmic expression of multiple enzymes involved in mammalian nitrogen homeostasis. In particular, Krüppel-like factor 15-deficient mice exhibit no discernable amino acid rhythm, and the rhythmicity of ammonia to urea detoxification is impaired. Of the external cues, feeding plays a dominant role in modulating Krüppel-like factor 15 rhythm and nitrogen homeostasis. Further, when all behavioral, environmental and dietary cues were controlled in humans, nitrogen homeostasis exhibited an endogenous circadian rhythmicity. Thus, in mammals, nitrogen homeostasis exhibits circadian rhythmicity, and is orchestrated by Krüppel-like factor 15.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/302326
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