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A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants

  • Barbez, Elke Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Bioinformatics, Ghent University, Belgium - Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Siences Vienna, Austria
  • Kubeš, Martin Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, Praha, Czech Republic
  • Rolčík, Jakub
  • Béziat, Chloé Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Bioinformatics, Ghent University, Belgium - Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Siences Vienna, Austria
  • Pěnčík, Aleš Centre of the Region Hana´ for Biotechnological and Agricultural Research, Department of Growth Regulators, Faculty of Science, Olomouc, Czech Republic
  • Wang, Bangjun Department of Biology - Plant Biology, University of Fribourg, Switzerland
  • Rosquete, Michel Ruiz Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Bioinformatics, Ghent University, Belgium - Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Siences Vienna, Austria
  • Zhu, Jinsheng Department of Biology - Plant Biology, University of Fribourg, Switzerland
  • Dobrev, Petre I. Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, Praha, Czech Republic
  • Lee, Yuree Department of Plant Molecular Biology, University of Lausanne, Switzerland
  • Zažímalovà, Eva Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, Praha, Czech Republic
  • Petrášek, Jan Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, Praha, Czech Republic
  • Geisler, Markus Department of Biology - Plant Biology, University of Fribourg, Switzerland
  • Friml, Jiří Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Bioinformatics, Ghent University, Belgium
  • Kleine-Vehn, Jürgen Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Bioinformatics, Ghent University, Belgium - Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Siences Vienna, Austria
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    15.04.2012
Published in:
  • Nature. - 2012, vol. 485, no. 7396, p. 119-122
English The phytohormone auxin acts as a prominent signal, providing, by its local accumulation or depletion in selected cells, a spatial and temporal reference for changes in the developmental program. The distribution of auxin depends on both auxin metabolism (biosynthesis, conjugation and degradation) and cellular auxin transport. We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required for auxin-dependent regulation of plant growth by determining the cellular sensitivity to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signalling. PILS activity affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via intracellular accumulation and metabolism. Our findings reveal that the transport machinery to compartmentalize auxin within the cell is of an unexpected molecular complexity and demonstrate this compartmentalization to be functionally important for a number of developmental processes.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/302222
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