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Unravelling adsorption and alignment of amyloid fibrils at interfaces by probe particle tracking

  • Isa, Lucio ETH Zurich, Laboratory for Surface Science and Technology, Zürich, Switzerland
  • Jung, Jin-Mi Department of Physics, University of Fribourg, Switzerland
  • Mezzenga, Raffaele ETH Zurich, Food and Soft Materials Science, Institute of Food, Nutrition & Health, Zurich, Switzerland
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  • Soft Matter. - 2011, vol. 7, p. 8127-8134
English We report the first direct, non-invasive experimental evidence of a 2D isotropic–nematic transition for highly anisotropic nanoparticles at liquid–liquid interfaces by using passive fluorescent particle tracking. In order to illustrate the potential of this approach on systems of high real practical and biological relevance, we select as a model anisotropic nanoparticles β-lactoglobulin amyloid fibrils of varying aspect ratios. Upon nanoparticle adsorption at the interface, we follow, in real time and as a function of fibril length and bulk concentration, the development of a 2D nematic phase by studying the anisotropy in probe particle traces. We furthermore demonstrate the long-range nature of the nematic phase by calculating order parameters for the traces as high as 0.8 over 10² to 10³ μm² areas. The presented route is independent of the system investigated, and thus these findings open a new, general strategy for the experimental assessment of 2D structural changes at anisotropic fluid–fluid interfaces.
Faculté des sciences et de médecine
Département de Physique
  • English
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