A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat

Boyer, Frédéric; Balado, Eric; Piazza, Pier V.; Dreyer, Jean-Luc; Deroche-Gamonet, Véronique

doi:10.1111/j.1369-1600.2010.00232.x

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A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat

Boyer, Frédéric Institute of Biochemistry, University of Fribourg, Switzerland
Balado, Eric INSERM U862, NeuroCentre Magendie, Pathophysiology of Addiction, Bordeaux, France and - Université de Bordeaux, Bordeaux, France
Piazza, Pier V. INSERM U862, NeuroCentre Magendie, Pathophysiology of Addiction, Bordeaux, France and - Université de Bordeaux, Bordeaux, France
Dreyer, Jean-Luc Institute of Biochemistry, University of Fribourg, Switzerland
Deroche-Gamonet, Véronique INSERM U862, NeuroCentre Magendie, Pathophysiology of Addiction, Bordeaux, France and - Université de Bordeaux, Bordeaux, France

23.06.2010

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Addiction Biology. - 2011, vol. 16, no. 1, p. 120–123

English Except as a marker of cancer progression, gamma-synuclein (GSyn) had received little attention. Recent data showed however that GSyn modulates cocaine-induced locomotor effects, suggesting that it could also play a role in cocaine reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected in the nucleus accumbens and cocaine reinforcing effects were evaluated by means of intravenous self-administration. A dose-response curve was followed by procedures of progressive ratio, extinction, cocaine- and cue-induced reinstatements. Decrease of GSyn expression increased self-administration over a large range of doses. This effect was associated with an increase in cocaine-induced reinstatement. The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects.

Faculty

Faculté des sciences et de médecine

Department

Département de Médecine

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