A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat
- Boyer, Frédéric Institute of Biochemistry, University of Fribourg, Switzerland
- Balado, Eric INSERM U862, NeuroCentre Magendie, Pathophysiology of Addiction, Bordeaux, France and - Université de Bordeaux, Bordeaux, France
- Piazza, Pier V. INSERM U862, NeuroCentre Magendie, Pathophysiology of Addiction, Bordeaux, France and - Université de Bordeaux, Bordeaux, France
- Dreyer, Jean-Luc Institute of Biochemistry, University of Fribourg, Switzerland
- Deroche-Gamonet, Véronique INSERM U862, NeuroCentre Magendie, Pathophysiology of Addiction, Bordeaux, France and - Université de Bordeaux, Bordeaux, France
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23.06.2010
Published in:
- Addiction Biology. - 2011, vol. 16, no. 1, p. 120–123
English
Except as a marker of cancer progression, gamma-synuclein (GSyn) had received little attention. Recent data showed however that GSyn modulates cocaine-induced locomotor effects, suggesting that it could also play a role in cocaine reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected in the nucleus accumbens and cocaine reinforcing effects were evaluated by means of intravenous self-administration. A dose-response curve was followed by procedures of progressive ratio, extinction, cocaine- and cue-induced reinstatements. Decrease of GSyn expression increased self-administration over a large range of doses. This effect was associated with an increase in cocaine-induced reinstatement. The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 27127
- DOI 10.1111/j.1369-1600.2010.00232.x
- Persistent URL
- https://folia.unifr.ch/unifr/documents/302054
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