High-level transgene expression by homologous recombination-mediated gene transfer
-
Grandjean, Mélanie
Laboratory of Molecular Biotechnology, Center for Biotechnology UNIL-EPFL, University of Lausanne, Switzerland
-
Girod, Pierre-Alain
Laboratory of Molecular Biotechnology, Center for Biotechnology UNIL-EPFL, University of Lausanne, Switzerland
-
Calabrese, David
Laboratory of Molecular Biotechnology, Center for Biotechnology UNIL-EPFL, University of Lausanne, Switzerland
-
Kostyrko, Kaja
Laboratory of Molecular Biotechnology, Center for Biotechnology UNIL-EPFL, University of Lausanne, Switzerland
-
Wicht, Marianne
Service of Medical Genetics, Center Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
-
Yerly, Florence
Department of Mathematics, University of Fribourg, Switzerland
-
Mazza, Christian
Department of Mathematics, University of Fribourg, Switzerland
-
Beckmann, Jacques S.
Service of Medical Genetics, Center Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
-
Martinet, Danielle
Service of Medical Genetics, Center Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
-
Mermod, Nicolas
Laboratory of Molecular Biotechnology, Center for Biotechnology UNIL-EPFL, University of Lausanne, Switzerland
Show more…
Published in:
- Nucleic Acid Research. - 2011, vol. 39, no. 15, p. e104
English
Gene transfer and expression in eukaryotes is often limited by a number of stably maintained gene copies and by epigenetic silencing effects. Silencing may be limited by the use of epigenetic regulatory sequences such as matrix attachment regions (MAR). Here, we show that successive transfections of MAR-containing vectors allow a synergistic increase of transgene expression. This finding is... Show more…
-
Faculty
- Faculté des sciences et de médecine
-
Department
- Département de Mathématiques
-
Language
-
-
Classification
-
Mathematics
-
License
-
License undefined
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/unifr/documents/301992