Journal article

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Activity-induced notch signaling in neurons requires arc/arg3.1 and is essential for synaptic plasticity in hippocampal networks

  • Alberi, Lavinia Department of Medicine/Anatomy, University of Fribourg, Rte Albert Gockel 1, 1700 Fribourg, Switzerland
  • Liu, Shuxi Institute for Cell Engineering, Neuroregeneration Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  • Wang, Yue Laboratory of Neuroscience, National Institute of Aging, Baltimore, MD 21224, USA
  • Badie, Ramy Institute for Cell Engineering, Neuroregeneration Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  • Smith-Hicks, Constance Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  • Wu, Jing Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  • Pierfelice, Tarran J. Institute for Cell Engineering, Neuroregeneration Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  • Abazyan, Bagrat Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  • Mattson, Mark P. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA - Laboratory of Neuroscience, National Institute of Aging, Baltimore, USA
  • Kuhl, Dietmar Institute for Molecular and Cellular Cognition, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Germany
  • Pletnikov, Mikhail Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA
  • Worley, Paul F. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA - Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
  • Gaiano, Nicholas Institute for Cell Engineering, Neuroregeneration Program, Johns Hopkins University School of Medicine, Baltimore, USA - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA - Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
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    09.02.2011
Published in:
  • Neuron. - 2011, vol. 69, no. 3, p. 437-444
French Notch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/301983
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