The daily rhythm of mice

Ripperger, Jürgen A.; Jud, Corinne; Albrecht, Urs

doi:10.1016/j.febslet.2011.02.027

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Journal article

The daily rhythm of mice

Ripperger, Jürgen A. Department of Medicine/Unit of Biochemistry, University of Fribourg, Switzerland
Jud, Corinne Adolphe Merkle Institute, University of Fribourg, Switzerland - Department of Medicine/Unit of Biochemistry, University of Fribourg, Switzerland
Albrecht, Urs Department of Medicine/Unit of Biochemistry, University of Fribourg, Switzerland

21.02.2011

Published in:

FEBS Letters. - 2011, vol. 585, no. 10, p. 1384-1392

English The house mouse Mus musculus represents a valuable tool for the analysis and the understanding of the mammalian circadian oscillator. Forward and reverse genetics allowed the identification of clock components and the verification of their function within the circadian clockwork. In many cases unforeseen links were discovered between a particular circadian regulatory protein and various diseases or syndromes. Thus, this model system is not only perfectly suited to pinpoint the components of the mammalian circadian clock, but also to unravel metabolic, physiological, and pathological processes linked to the circadian timing system.

Faculty

Faculté des sciences et de médecine

Department

Département de Biologie

Language