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Coexistence of copy number increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in ovarian cancers

  • Dimova, Ivanka Department of Medical Genetics, Medical University Sofia, Bulgaria - Institute of Anatomy, University of Fribourg, Switzerland
  • Raicheva, Sashka Laboratory of Gynecopathology, University Hospital of Obstetrics and Gynecology, Sofia, Bulgaria
  • Dimitrov, Rumen Second Gynecologic Clinic, University Hospital of Obstetrics and Gynecology, Sofia, Bulgaria
  • Doganov, Nikolai Second Gynecologic Clinic, University Hospital of Obstetrics and Gynecology, Sofia, Bulgaria
  • Toncheva, Draga Department of Medical Genetics, Medical University Sofia, Bulgaria
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    20.06.2009
Published in:
  • Onkologie. - 2009, vol. 32, no. 7, p. 405-410
Ovarian cancer
Oncogenes
Genomic imbalances
Fluorescence in situ hybridization
English Background: We selected 5 oncogenes with well-established roles in carcinogenesis – CCND1, ErbB1, ErbB2, c-mycand ZNF217– to investigate the coexistence of their copy imbalances in relation to the clinico-pathological characteristics of ovarian tumors. Materials and Methods: Fluorescence in situ hybridization for the 5 genes was applied to a preexisting tissue microarray. 38 ovarian tumors were successfully analyzed for copy number changes of the 5 genes. Results: At least one of these oncogenes was gained/amplified in 27 out of 38 tumors (71.1). We report the highest frequency of c-mycgenetic gain/amplification since it affected 42.1 of the ovarian tumors. We observed sequential involvement of copy number alterations of the other genes in the presence of c-mycdisruption. The incidence of copy number changes of the 5 oncogenes – both single and combinatorial – was higher in high-grade tumors. All double aberrations in the serous group comprised c-mycand ZNF217copy number increases. Conclusions: Our results revealed a combination between copy number increases of c-mycand ZNF217, associated with serous histology. The data from this combined analysis of the 5 oncogenes could be used as a basis in considering the combined approach in molecular-based therapy of ovarian cancer.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/301873
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